When the U Wave Tells the Story: Andersen–Tawil Syndrome Unmasked

A 26-year-old woman with recurrent syncope was diagnosed with Andersen-Tawil syndrome (ATS) following abnormal electrocardiographic (ECG) findings. Her history of ventricular arrhythmias and prominent U waves on ECG led to genetic testing, which identified a KCNJ2 mutation. This case underscores the importance of recognizing ATS-specific ECG patterns, including broad U waves, in diagnosing arrhythmias. Following medication adjustments, her symptoms improved, highlighting the significance of tailored treatment for ATS-associated arrhythmias.

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Publication Details

Journal
Annals of Noninvasive Electrocardiology
Published
2025-10-23
DOI
https://doi.org/10.1111/anec.70119
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
0.00
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article

When the U Wave Tells the Story: Andersen–Tawil Syndrome Unmasked

Shasha Yu, Hang Lv
Annals of Noninvasive Electrocardiology
Cardiac electrophysiology and arrhythmias
article

When the U Wave Tells the Story: Andersen–Tawil Syndrome Unmasked

Shasha Yu, Hang Lv
article en

Abstract

A 26-year-old woman with recurrent syncope was diagnosed with Andersen-Tawil syndrome (ATS) following abnormal electrocardiographic (ECG) findings. Her history of ventricular arrhythmias and prominent U waves on ECG led to genetic testing, which identified a KCNJ2 mutation. This case underscores the importance of recognizing ATS-specific ECG patterns, including broad U waves, in diagnosing arrhythmias. Following medication adjustments, her symptoms improved, highlighting the significance of tailored treatment for ATS-associated arrhythmias.

Annals of Noninvasive ElectrocardiologyVol. 30(6)
Wuhan University (CN), Wuhan Asia Heart Hospital (CN), Wuhan General Hospital of Guangzhou (CN)
Openalex Percentile: Top 54%
Cardiac electrophysiology and arrhythmias
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