IL-1 targeting agents in Schnitzler syndrome: a multicentre, real-world study from the international AIDA Network Schnitzler Registry
The present study confirms the high effectiveness of IL-1 inhibitors in controlling SchS, including the complete and partial response rates and the long-term survival. Elevated IgG M-protein levels and the presence of lymphadenopathy should be considered as potential indicators for identifying patients more likely to exhibit a partial response and a possible loss of treatment efficacy.
Authors
- Martina D’Onghia (ORCID: https://orcid.org/0000-0001-8315-3413)
- Andreas Recke (ORCID: https://orcid.org/0000-0002-7674-1804)
- Andrea Hinojosa‐Azaola (ORCID: https://orcid.org/0000-0002-4001-3995)
- Leyla La Cava
- Bruno Frediani (ORCID: https://orcid.org/0000-0001-6003-7567)
- Giuseppe Lopalco (ORCID: https://orcid.org/0000-0003-4524-9566)
- Laura Calabrese (ORCID: https://orcid.org/0000-0001-5238-2336)
- Franco Franceschini (ORCID: https://orcid.org/0000-0003-3678-6124)
- Valeria Caggiano (ORCID: https://orcid.org/0000-0002-9907-4856)
- Antonio Vitale (ORCID: https://orcid.org/0000-0003-4469-7332)
- Ombretta Viapiana (ORCID: https://orcid.org/0000-0003-1917-5655)
- Hamit Küçük (ORCID: https://orcid.org/0000-0003-1206-4725)
- Abdurrahman Tufan (ORCID: https://orcid.org/0000-0001-6244-9362)
- Paolo Sfriso (ORCID: https://orcid.org/0000-0001-6432-7174)
- Francesca Crisafulli (ORCID: https://orcid.org/0000-0003-0319-1538)
- Alberto Balistreri (ORCID: https://orcid.org/0000-0002-7349-9725)
- Karina Jahnz‐Różyk (ORCID: https://orcid.org/0000-0002-3505-1858)
- Aslıhan Avanoğlu Güler (ORCID: https://orcid.org/0000-0001-9866-9797)
- Ewa Więsik–Szewczyk (ORCID: https://orcid.org/0000-0001-8509-4453)
- Luca Cantarini (ORCID: https://orcid.org/0000-0002-7352-1275)
- Alessandra Cartocci (ORCID: https://orcid.org/0000-0002-1818-6275)
- Francesca Della Casa (ORCID: https://orcid.org/0000-0002-0115-1420)
- Élisa Cinotti (ORCID: https://orcid.org/0000-0002-4009-0659)
- Giacomo Emmi (ORCID: https://orcid.org/0000-0001-9575-8321)
- Eduardo Martín‐Nares (ORCID: https://orcid.org/0000-0002-7911-1269)
- Antonio Gidaro (ORCID: https://orcid.org/0000-0002-5379-1091)
- Jiram Torres‐Ruiz (ORCID: https://orcid.org/0000-0002-7882-1488)
- Pietro Rubegni (ORCID: https://orcid.org/0000-0002-7762-9312)
- Sara M. Monti (ORCID: https://orcid.org/0000-0002-1800-6772)
- Katarzyna Rybak (ORCID: https://orcid.org/0000-0003-3595-0818)
- Ilaria Mormile (ORCID: https://orcid.org/0000-0001-7599-5426)
- Micol Frassi
- Jurgen Sota (ORCID: https://orcid.org/0000-0002-7549-2922)
- Claudia Fabiani (ORCID: https://orcid.org/0000-0003-4515-7741)
- Stefania Costi (ORCID: https://orcid.org/0000-0002-4468-6839)
- Roberta Lopez
- Jessica Sbalchiero
Institutions
- University of Siena (IT)
- University of Pavia (IT)
- Luigi Sacco Hospital (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Ospedale di Cattinara (IT)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- University Hospital Schleswig-Holstein (DE)
- Institute for Rheumatic Diseases (Japan) (JP)
- Azienda Ospedaliera Universitaria Senese (IT)
- Central Clinical Hospital (PL)
- ERN GUARD-Heart (NL)
- Policlinico San Matteo Fondazione (IT)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
- University of Brescia (IT)
- University of Lübeck (DE)
- Gazi University (TR)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.55563/clinexprheumatol/i9hsfr
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Siena