Assessing new treatments for central sleep Apnoea in heart failure: sample size considerations for reliable detection of safety signals
Future clinical trials investigating treatments for CSA/CSR in HFrEF patients must incorporate sufficient sample sizes and event counts to ensure reliable detection of safety signals, particularly concerning all-cause mortality. This approach is critical for accurately assessing the risk-benefit profile of new therapeutic interventions.
Authors
- Holger Woehrle (ORCID: https://orcid.org/0000-0001-6588-5039)
- Eik Vettorazzi (ORCID: https://orcid.org/0000-0002-3737-6402)
- Patrick Lévy (ORCID: https://orcid.org/0000-0003-3174-7935)
- Adam Benjafield (ORCID: https://orcid.org/0000-0003-4716-2827)
- Michael Arzt (ORCID: https://orcid.org/0000-0002-4408-722X)
- Raphael C. Heinzer (ORCID: https://orcid.org/0000-0002-3215-7788)
- Karl Wegscheider (ORCID: https://orcid.org/0000-0003-2974-3142)
- Jean‐Louis Pépin (ORCID: https://orcid.org/0000-0003-3832-2358)
- Peter A. Cistulli (ORCID: https://orcid.org/0000-0002-7920-4924)
- Martín Cowie (ORCID: https://orcid.org/0000-0001-7457-2552)
- Atul Malhotra (ORCID: https://orcid.org/0000-0002-7021-9302)
- Anita K. Simonds
Institutions
- Inserm (FR)
- Universität Hamburg (DE)
- Universität Ulm (DE)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Royal North Shore Hospital (AU)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Centre Hospitalier Universitaire Vaudois (CH)
- Harefield Hospital (GB)
- University Hospital Regensburg (DE)
- University of California San Diego (US)
- Royal Brompton Hospital (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- ResMed (Australia) (AU)
- Université Grenoble Alpes (FR)
- University of Lausanne (CH)
Publication Details
- Journal
- Sleep And Breathing
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1007/s11325-025-03517-7
- Citations
- 1
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.39