Efficacy and Safety of Protamine Use following Transcatheter Aortic Valve Implantation for Minimizing Post-Procedural Bleeding Risk: A Systematic Review and Meta-Analysis
Protamine use after TAVI appeared to be safe with no increase in 30-day mortality or stroke and TIA rates, but there was no observed statistically significant benefit in the reduction of major or life-threatening bleeding events and the need for blood transfusions. These findings are based on a limited number of studies, and larger randomized controlled trials are warranted to confirm them.
Authors
- Hatim Nasruldin Shahin (ORCID: https://orcid.org/0009-0004-4658-0984)
- Arowa Alansari
- Ali Abdelaziz (ORCID: https://orcid.org/0009-0007-1940-4258)
- Muhammed Elhadi (ORCID: https://orcid.org/0000-0001-6406-4212)
- Mamas A. Mamas (ORCID: https://orcid.org/0000-0001-9241-8890)
- Mohammed S. Beshr (ORCID: https://orcid.org/0009-0007-0113-5117)
- H Almezghwi
- Anas Atiyah Abdulsalam
- Abdelrahman Farag
- Arwi Omar Kara
- Alhasan Saleh Alzubi (ORCID: https://orcid.org/0009-0005-1780-9409)
- Esraa Arhaym
- Dania Mukhtar Mukhtar Aburawi
- Mostafa El Awami (ORCID: https://orcid.org/0009-0002-4777-0013)
Institutions
- Sana'a University (YE)
- East Carolina University (US)
- South Valley University (EG)
- Korea University (KR)
- University of Tripoli (LY)
- Omar Al-Mukhtar University (LY)
- University of Benghazi (LY)
- Keele University (GB)
- Alexandria University (EG)
- Marshall University (US)
Publication Details
- Journal
- Cardiology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1159/000549115
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00