Correlation between Blood Uric Acid Fluctuation and Prognosis in Patients with Chronic Kidney Disease Combined with Hyperuricemia: A Multicenter Real-World Study

(1) With follow-up over different time periods, bigger SUA fluctuations are linked to higher risks of CKD progression, all-cause mortality, and cardiovascular death; as follow-up time increases, the correlation between the highest SUA variability and CKD progression risk gradually decreases, which may relate to the increasing confounding factors as CKD progresses over time. (2) In the northeastern population of China and among patients treated with sodium bicarbonate, greater SUA fluctuations are associated with higher all-cause mortality risk. During the 24-month follow-up period, the risk of MACE results due to SUA fluctuations was not significantly associated with the population; SUA fluctuations in populations with tumors, diabetes, hyperkalemia, metabolic acidosis, gender, and those treated with febuxostat do not show a significant link to all-cause mortality risk.