Distinct human small intestinal microbiome communities underlie visceral hypersensitivity in a humanized mouse model
Specific small-intestinal bacteria, particularly Enterobacteriaceae, can trigger abdominal pain by activating gut sensory and nerve cells, revealing how microbiota contribute to gastrointestinal symptoms.
Authors
- Arthur Beyder (ORCID: https://orcid.org/0000-0002-9225-4854)
- Gianrico Farrugia
- Kristen Smith (ORCID: https://orcid.org/0000-0002-9330-4454)
- Arnaldo Mercado‐Perez (ORCID: https://orcid.org/0000-0001-8036-6771)
- Ruben A. Mars (ORCID: https://orcid.org/0000-0002-3917-9517)
- Prabhjot Kaur Sekhon (ORCID: https://orcid.org/0000-0002-4587-3951)
- Lisa Till (ORCID: https://orcid.org/0000-0003-4943-3125)
- Işın Y. Comba (ORCID: https://orcid.org/0000-0002-0955-6270)
- Shreya S. Bellampalli (ORCID: https://orcid.org/0000-0003-3969-1155)
- David R. Linden (ORCID: https://orcid.org/0000-0002-1727-0387)
- Purna Kashyap (ORCID: https://orcid.org/0000-0002-2851-2388)
- Tijs Louwies (ORCID: https://orcid.org/0000-0003-4860-6100)
- Brian S. Edwards (ORCID: https://orcid.org/0000-0002-8382-4755)
- Robin Shields‐Cutler (ORCID: https://orcid.org/0000-0003-4701-9895)
- Adam Willits
- Yang Xiao (ORCID: https://orcid.org/0000-0003-1058-9536)
- Dennis R. Tienter
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- Macalester College (US)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1172/jci190638
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81