A Prospective Observational Study on the Evaluation of the Galactomannan Test in the Diagnosis of Invasive Aspergillosis

In this cohort, BAL GM testing provided excellent sensitivity and, especially at OD > 1.0, improved specificity relative to conventional methods. Serum GM performed moderately well, but with lower sensitivity and specificity. BAL GM (OD > 1.0) may provide an optimal balance for non-culture-based diagnosis of IA, though results should be interpreted in the clinical context. Future multicenter studies incorporating polymerase chain reaction (PCR) and β-D-glucan are warranted to validate these findings.