Rh(III)-Catalyzed Regioselective B(4)–H Alkylation of <i>o</i> -Carboranes with Alkenes
Herein, we describe a versatile Rh(III)-catalyzed platform for the exclusive B(4)-H alkylation of <i>o</i>-carborane, needing only one equivalent of alkenes (40 examples, up to 90% yield). Notably, this approach deviates significantly from established pathways that typically yield alkenylated products in carborane-alkene reactions. Mechanistic analysis indicates that monoalkylation selectivity is kinetically regulated by the post-coordination of the monoalkylated product to Rh(III).
Authors
- Hou‐Ji Cao (ORCID: https://orcid.org/0000-0002-0539-9124)
- Hong Yan (ORCID: https://orcid.org/0000-0003-3993-0013)
- Qianyi Zhao (ORCID: https://orcid.org/0000-0002-4113-3155)
- Meijiu Liu
- Jiaxin Li (ORCID: https://orcid.org/0000-0003-4207-1192)
- Jia-Hui Yan
- Ju Zhang (ORCID: https://orcid.org/0000-0003-3274-9844)
- Mingwei Zhao (ORCID: https://orcid.org/0000-0002-6120-5654)
- R. Ma (ORCID: https://orcid.org/0000-0002-8065-5992)
Institutions
- Henan Normal University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1021/acs.orglett.5c03574
- Citations
- 1
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.36