Cardiovascular Risk Through Hypoxic Burden in Children With Sleep Apnea
In this secondary analysis of a nonrandomized clinical trial, elevated HB values were associated with an NDP and reduced nocturnal decrease in BP in children with OSA, both of which are established markers of CV risk. These results suggest the potential utility of HB as a biomarker for CV risk stratification and clinical management in the pediatric population with OSA.
Authors
- Laura Silgado-Martínez
- Carles Forné (ORCID: https://orcid.org/0000-0002-8133-3274)
- Laura Fidalgo
- Alfonso Ortigado (ORCID: https://orcid.org/0000-0003-3680-4855)
- Olga Mediano (ORCID: https://orcid.org/0000-0001-7824-1523)
- Ainhoa Álvarez Ruiz De Larrínaga (ORCID: https://orcid.org/0000-0002-4193-0197)
- Esther Solano-Pérez (ORCID: https://orcid.org/0009-0000-1259-9899)
- Sofía Romero-Peralta (ORCID: https://orcid.org/0000-0002-3522-1992)
- Irene Cano‐Pumarega (ORCID: https://orcid.org/0000-0003-1543-7187)
- María Esther Viejo-Ayuso
- Pilar Resano-Barrio (ORCID: https://orcid.org/0000-0001-8518-6446)
- Francisco García‐Río (ORCID: https://orcid.org/0000-0002-7227-2238)
- Ali Azarbarzin (ORCID: https://orcid.org/0000-0002-4986-4753)
- Leticia Álvarez-Balado
- Manuel Sánchez‐de‐la‐Torre (ORCID: https://orcid.org/0000-0002-5695-348X)
- Sonia López-Monzoni
- María Castillo-García
- J. Mora (ORCID: https://orcid.org/0009-0008-0670-9340)
- Ángel Rodríguez
- Belén García-Mediano
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Universitat de Lleida (ES)
- Universidad de Alcalá (ES)
- Hospital Universitario La Paz (ES)
- Hospital Universitario de Guadalajara (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Hospital Universitario Araba (ES)
- Osakidetza (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Circadian (United States) (US)
- Servicio de Salud de Castilla La Mancha (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.38744
- Citations
- 1
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Sociedad Española de Neumología y Cirugía Torácica
- Instituto de Salud Carlos III
- European Regional Development Fund