Multiomic Selection of Cancer-Testis Antigens as Precision Immuno-oncologic Targets in Head and Neck Cancer
In this study, a set of 23 testis-restricted and 44 testis-selective CTAs were orthogonally validated in multiple tumor datasets. Of these, a core set of 14 CTAs were consistently detected across all datasets. Their tumor specificity and broad expression bolster their potential as promising precision immuno-oncologic targets for future T-cell receptor engineering efforts.
Authors
- Musaddiq J. Awan (ORCID: https://orcid.org/0000-0002-1063-7932)
- Jamie Foeckler
- Michael Stadler (ORCID: https://orcid.org/0009-0002-1597-9146)
- Jennifer Bruening (ORCID: https://orcid.org/0000-0001-6246-8731)
- Heather A. Himburg (ORCID: https://orcid.org/0000-0002-9676-6371)
- Kenneth E. Akakpo (ORCID: https://orcid.org/0000-0003-4720-7626)
- Stuart J. Wong (ORCID: https://orcid.org/0000-0002-0447-871X)
- Abdullah A. Memon (ORCID: https://orcid.org/0009-0009-9062-7619)
- Anne Frei
- Joseph Zenga
- Oscar Villarreal Espinosa
- Becky Massey
- Rachel Kuehn (ORCID: https://orcid.org/0009-0002-5862-250X)
Institutions
- Medical College of Wisconsin (US)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1001/jamaoto.2025.3563
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00