A commercial bacteriophage cocktail failed to decolonize Zophobas morio larvae and promoted overgrowth of an OXA-48-producing Salmonella enterica
ZmL can be used as a new in vivo model of intestinal colonization with S. enterica. However, INTESTIbc administration failed to achieve decolonization and instead promoted hazardous overgrowth of the inoculated pathogen. These findings highlight the need for further investigations to clarify the therapeutic potential or possible risks of broad-spectrum bacteriophage cocktails against intestinal infections/colonization caused by hyperepidemic S. enterica clones.
Authors
- Claudia Aldeia (ORCID: https://orcid.org/0009-0007-5475-961X)
- Andrea Endimiani (ORCID: https://orcid.org/0000-0003-3186-5421)
- Edgar I. Campos-Madueno (ORCID: https://orcid.org/0000-0002-1846-9857)
Institutions
- University of Bern (CH)
- Bern University of Applied Sciences (CH)
Publication Details
- Journal
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1007/s10096-025-05275-6
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00