Biomarker-based risk assessment of dietary intervention in patients with coronary artery disease during cardiac rehabilitation—a quasi-experimental study
No additional immediate benefit in risk reduction during CR for low-carb or low-fat dietary interventions was detected. However, the low-fat and low-carb diet resulted in significantly greater reductions in BMI, body fat and visceral fat, with a tendency towards more stable effects over 6 months in the low-fat group. While glycemic control was improved in the low-carb group during inpatient CR, long-term adherence appeared challenging, particularly for diabetic patients as HbA1c levels re-increased during 6 months follow-up. Since no difference in MACCE was seen, the dietary interventions may be considered equally safe for CAD patients.
Authors
- Frank C. Mooren (ORCID: https://orcid.org/0000-0002-0258-2732)
- Hendrik Schäfer (ORCID: https://orcid.org/0000-0001-8598-9003)
- Boris Schmitz (ORCID: https://orcid.org/0000-0001-7041-7424)
- Hubert Scharnagl (ORCID: https://orcid.org/0000-0002-2750-006X)
- Gereon Böll
- Marc Teschler (ORCID: https://orcid.org/0000-0002-5613-6703)
- Marcus E. Kleber (ORCID: https://orcid.org/0000-0003-0663-7275)
- Mona Kotewitsch
- René Garbsch (ORCID: https://orcid.org/0000-0001-7428-5692)
- Melina Waranski (ORCID: https://orcid.org/0009-0006-1338-8560)
- Katalin Vereckei
- Alexander Dressel (ORCID: https://orcid.org/0000-0002-7630-7223)
- Winfried März
- Dennis Köstler
Institutions
- Synlab Czech (Czechia) (CZ)
- Witten/Herdecke University (DE)
- Medical University of Graz (AT)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Synlab (Germany) (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fnut.2025.1669931
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Deutsche Rentenversicherung
- European Commission