Impaired Perfusion and Early Ischemic Stroke Recurrence in Symptomatic Intracranial Atherosclerosis: BIORISK ICAS Study
Biomarkers of impaired distal perfusion, anterior circulation borderzone infarct, and hypoperfusion mismatch were associated with increased risk of recurrent ischemic stroke. These findings support the use of perfusion imaging in ICAS as well as future trials investigating early reperfusion in high-risk patients with ICAS.
Authors
- Valeria Terruso
- Ananth K. Vellimana (ORCID: https://orcid.org/0000-0003-2056-6610)
- William Almiri (ORCID: https://orcid.org/0000-0002-4217-4071)
- Osama O. Zaidat (ORCID: https://orcid.org/0000-0003-4881-4698)
- Ekaterina Bakradze (ORCID: https://orcid.org/0000-0001-7534-7218)
- Camila Bonin Pinto (ORCID: https://orcid.org/0000-0003-2820-8703)
- Faddi Ghassan Saleh Vélez (ORCID: https://orcid.org/0000-0002-2626-6259)
- Karen L. Furie (ORCID: https://orcid.org/0000-0003-0065-3784)
- Thaís Secchi (ORCID: https://orcid.org/0000-0001-5214-7037)
- Cheran Elangovan (ORCID: https://orcid.org/0000-0002-9473-8051)
- James P. Klaas (ORCID: https://orcid.org/0000-0003-1563-528X)
- Sridhara Yaddanapudi (ORCID: https://orcid.org/0000-0002-9024-0838)
- Aditya Jhaveri (ORCID: https://orcid.org/0009-0002-1305-0819)
- Hadley W. Ressler (ORCID: https://orcid.org/0000-0002-7027-1901)
- Maarij Malik (ORCID: https://orcid.org/0000-0002-0315-7631)
- Pablo Harker (ORCID: https://orcid.org/0000-0003-0263-8748)
- Shayak Sen
- Argyro Tountopoulou (ORCID: https://orcid.org/0000-0002-3276-588X)
- David S. Liebeskind (ORCID: https://orcid.org/0000-0002-5109-8736)
- Shadi R. Yaghi (ORCID: https://orcid.org/0000-0003-0031-1004)
- Margy McCullough‐Hicks (ORCID: https://orcid.org/0000-0003-3770-8689)
- Mafalda Soares (ORCID: https://orcid.org/0000-0002-7508-0645)
- Balaji Krishnaiah (ORCID: https://orcid.org/0000-0002-5825-1799)
- Lindsey Kuohn (ORCID: https://orcid.org/0000-0001-9500-6162)
- Michele Romoli (ORCID: https://orcid.org/0000-0001-8009-8543)
- Cameron D. Owens (ORCID: https://orcid.org/0000-0002-5020-2810)
- Muhammad Aemaz Ur Rehman (ORCID: https://orcid.org/0000-0002-9017-8659)
- Sheila Cristina Ouriques Martins (ORCID: https://orcid.org/0000-0002-8452-712X)
- Muhib Khan (ORCID: https://orcid.org/0000-0001-6329-8703)
- Liqi Shu (ORCID: https://orcid.org/0000-0002-9784-8475)
- Mahasen Reda
- Ingrid Kugler
- Kateryna Antonenko (ORCID: https://orcid.org/0000-0002-1936-5451)
- Yasmin Tarek Ali Abdel Aziz (ORCID: https://orcid.org/0000-0002-3515-4005)
- Gabriel Paulo Mantovani (ORCID: https://orcid.org/0000-0003-3187-0220)
- Mahmoud Dibas (ORCID: https://orcid.org/0000-0003-1690-1084)
- Mohammad W Khasawneh (ORCID: https://orcid.org/0000-0002-9944-2495)
- Varsha Muddasani (ORCID: https://orcid.org/0000-0002-4225-8558)
- James Ernest Siegler (ORCID: https://orcid.org/0000-0003-0287-3967)
- Benan Barakat (ORCID: https://orcid.org/0000-0001-6511-3848)
- Nils Henninger (ORCID: https://orcid.org/0000-0002-3883-5623)
- Marina Mannino (ORCID: https://orcid.org/0000-0001-7683-7235)
- Sami Al Kasab (ORCID: https://orcid.org/0000-0001-8909-9761)
- Adam de Havenon (ORCID: https://orcid.org/0000-0001-8178-8597)
- Christopher R. Leon Guerrero (ORCID: https://orcid.org/0000-0002-5997-5342)
- Shyam Prabhakaran (ORCID: https://orcid.org/0000-0003-0724-1694)
- Amanda Cyntia Lima Fonseca Rodrigues (ORCID: https://orcid.org/0000-0002-1020-0060)
- Thanh N. Nguyen (ORCID: https://orcid.org/0000-0002-2810-1685)
- João Pedro Marto (ORCID: https://orcid.org/0000-0003-2277-5950)
- Rami Z. Morsi (ORCID: https://orcid.org/0000-0003-2131-3711)
- Ryan Apfel (ORCID: https://orcid.org/0000-0003-4992-6704)
- Rui Duarte Armindo (ORCID: https://orcid.org/0000-0003-0001-742X)
- Dawson C Cooper (ORCID: https://orcid.org/0000-0003-2508-0636)
- Hieu Tran (ORCID: https://orcid.org/0000-0001-8449-3719)
- Diana Aguiar de Sousa (ORCID: https://orcid.org/0000-0002-6702-7924)
- Jennifer Frontera (ORCID: https://orcid.org/0000-0002-0719-2522)
- Christel Tamer
- M S Mayer
- Krithika Umesh Peshwe
- Pooja Kumari Khatri (ORCID: https://orcid.org/0000-0002-7344-8266)
- Venugopalan Y. Vishnu (ORCID: https://orcid.org/0000-0002-3654-8137)
- Amir M. Molaie (ORCID: https://orcid.org/0000-0001-7184-8613)
- Ajay Tunguturi
- Alexis N. Simpkins (ORCID: https://orcid.org/0000-0001-7529-4267)
- Tarek El Halabi (ORCID: https://orcid.org/0000-0002-1197-1393)
- Ayush Agarwal (ORCID: https://orcid.org/0000-0003-2303-1961)
- Richard Choi (ORCID: https://orcid.org/0000-0003-1915-8775)
- Nazir Khan
- Malik Ghannam (ORCID: https://orcid.org/0000-0003-2350-284X)
- Kelly L. Sloane (ORCID: https://orcid.org/0000-0001-9680-9565)
- Aaron Rothstein (ORCID: https://orcid.org/0000-0002-8480-8220)
- Mirjam R. Heldner (ORCID: https://orcid.org/0000-0002-3594-2159)
- Piers Klein (ORCID: https://orcid.org/0000-0001-7468-137X)
- Abhiram Parameswaran Pillai
- Mariana Lima Coelho (ORCID: https://orcid.org/0009-0001-3487-027X)
- João Sargento‐Freitas (ORCID: https://orcid.org/0000-0003-4665-5697)
- Meena Chandu
- Linda Sherine Alfred (ORCID: https://orcid.org/0009-0004-8737-8256)
- Mohammad Almajali (ORCID: https://orcid.org/0000-0001-5051-6687)
- Yan Hou (ORCID: https://orcid.org/0000-0003-3901-9916)
- Farhan Khan (ORCID: https://orcid.org/0000-0002-5958-6881)
- Praveen Hariharan (ORCID: https://orcid.org/0000-0002-0115-3354)
- Mohamed Elshikh (ORCID: https://orcid.org/0000-0003-0106-3647)
- Sofia Vassilopoulou (ORCID: https://orcid.org/0000-0003-1540-8650)
- João André Sousa (ORCID: https://orcid.org/0000-0002-5199-6210)
- Johanna Helenius
- Ahmad Abu Qdais (ORCID: https://orcid.org/0009-0002-8616-1712)
- Ava Stipanovich
- Shaista Alam
- Sabiha Sultana (ORCID: https://orcid.org/0000-0001-9577-0371)
- Richard Baker
- S. Bhati
- Skylar Lewis
- Nicola Marrone
- Stefano Vozzi
Institutions
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- University of Iowa (US)
- University of Maryland, Baltimore (US)
- Christiana Care Health System (US)
- Cedars-Sinai Medical Center (US)
- Lahey Hospital and Medical Center (US)
- Mercy St. Vincent Medical Center (US)
- Hartford Hospital (US)
- Mayo Clinic (US)
- University of Lisbon (PT)
- Thomas Jefferson University (US)
- Medical University of South Carolina (US)
- University of Tennessee Health Science Center (US)
- University of California, Los Angeles (US)
- University of Massachusetts Chan Medical School (US)
- National and Kapodistrian University of Athens (GR)
- Washington University in St. Louis (US)
- Brown University (US)
- University Hospital of Bern (CH)
- University of Alabama at Birmingham (US)
- Yale University (US)
- University of Chicago (US)
- Hospital Moinhos de Vento (BR)
- Unidade Local de Saúde de São José (PT)
- Hospital de Clínicas de Porto Alegre (BR)
- Ospedale Vincenzo Cervello (IT)
- Twin Cities Orthopedics (US)
- American University of Beirut Medical Center (LB)
- Atrium Medical Cente (US)
- Christiana Hospital (US)
- Lahey Medical Center (US)
- Hospital de Egas Moniz (PT)
- Ospedale “M. Bufalini” di Cesena (IT)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Hospital de Clínicas (UY)
- Jersey Shore University Medical Center (US)
- University of Houston (US)
- Wake Forest University (US)
- University of Oklahoma Health Sciences Center (US)
- New York University (US)
- University of Cincinnati (US)
- All India Institute of Medical Sciences (IN)
- University of Coimbra (PT)
- University of Pennsylvania (US)
- MedStar Health (US)
- American University of Beirut (LB)
Publication Details
- Journal
- Stroke
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1161/strokeaha.125.053160
- Citations
- 1
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.52