Transpulmonary eicosanoid metabolite gradients: insights into metabolic flux of pro- and anti-inflammatory metabolites and lung function
Using multisite sampling and molecular profiling, we identified specific eicosanoids with metabolic flux across the pulmonary circulation. Differential transpulmonary gradients of pro-inflammatory and anti-inflammatory eicosanoids were associated with abnormal lung function, underscoring potential relevance to chronic lung disease.
Authors
- Jennifer E. Ho (ORCID: https://orcid.org/0000-0002-7987-4768)
- Gregory D. Lewis (ORCID: https://orcid.org/0000-0001-8108-8240)
- Louisa A. Mounsey (ORCID: https://orcid.org/0000-0001-5244-0647)
- Jenna McNeill (ORCID: https://orcid.org/0000-0001-7032-4228)
- Mona Alotaibi (ORCID: https://orcid.org/0000-0001-8492-9930)
- Mohit Jain (ORCID: https://orcid.org/0000-0001-8628-2069)
- Juhi K. Parekh (ORCID: https://orcid.org/0009-0009-6510-0073)
- Sophie M. Nemeth
Institutions
- Cedars-Sinai Medical Center (US)
- Beth Israel Deaconess Medical Center (US)
- Duke University (US)
- University of California System (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- Cedars-Sinai Smidt Heart Institute (US)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1183/23120541.01133-2025
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00