Co-existing phaeochromocytoma and anti-HMG-CoA reductase immune-mediated necrotising myositis: a diagnostic challenge

Immune-mediated necrotising myopathy (IMNM) should be considered in patients with a history of statin use presenting with muscle weakness and elevated creatine kinase that fails to improve after statin cessation. Early diagnosis and immunosuppressive therapy are crucial in preventing permanent muscle damage. When IMNM is suspected clinically, work-up should include prompt testing for anti-HMGCR antibodies in serum. Rare conditions can co-exist, and multidisciplinary care in managing complex cases improves patient outcome.

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Publication Details

Journal
Endocrinology Diabetes and Metabolism Case Reports
Published
2025-10-01
DOI
https://doi.org/10.1530/edm-25-0052
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
Field-Weighted Citation Impact
0.00
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article

Co-existing phaeochromocytoma and anti-HMG-CoA reductase immune-mediated necrotising myositis: a diagnostic challenge

Rachel Crowley, Eric Heffernan, Sarah Fullam, Eibhlin Lonergan et al.
Endocrinology Diabetes and Metabolism Case Reports
Inflammatory Myopathies and Dermatomyositis
article

Co-existing phaeochromocytoma and anti-HMG-CoA reductase immune-mediated necrotising myositis: a diagnostic challenge

Rachel Crowley, Eric Heffernan, Sarah Fullam, Eibhlin Lonergan, Brian O’Riordan, Seán Connolly, Sean Maher, Carl Orr, Ruth Prichard
article en

Abstract

Immune-mediated necrotising myopathy (IMNM) should be considered in patients with a history of statin use presenting with muscle weakness and elevated creatine kinase that fails to improve after statin cessation. Early diagnosis and immunosuppressive therapy are crucial in preventing permanent muscle damage. When IMNM is suspected clinically, work-up should include prompt testing for anti-HMGCR antibodies in serum. Rare conditions can co-exist, and multidisciplinary care in managing complex cases improves patient outcome.

Endocrinology Diabetes and Metabolism Case ReportsVol. 2025(4)
University College Dublin (IE), St. Vincent's University Hospital (IE)
Openalex Percentile: Top 59%
Inflammatory Myopathies and Dermatomyositis
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Co-existing phaeochromocytoma and anti-HMG-CoA reductase immune-mediated necrotising myositis: a diagnostic challenge — Rachel Crowley, Eric Heffernan, et al. · Endocrinology Diabetes and Metabolism Case Reports (2025) | TGRS Research Map | TGRS