Co-existing phaeochromocytoma and anti-HMG-CoA reductase immune-mediated necrotising myositis: a diagnostic challenge
Immune-mediated necrotising myopathy (IMNM) should be considered in patients with a history of statin use presenting with muscle weakness and elevated creatine kinase that fails to improve after statin cessation. Early diagnosis and immunosuppressive therapy are crucial in preventing permanent muscle damage. When IMNM is suspected clinically, work-up should include prompt testing for anti-HMGCR antibodies in serum. Rare conditions can co-exist, and multidisciplinary care in managing complex cases improves patient outcome.
Authors
- Rachel Crowley (ORCID: https://orcid.org/0000-0003-1472-4117)
- Eric Heffernan
- Sarah Fullam (ORCID: https://orcid.org/0000-0002-9657-5823)
- Eibhlin Lonergan
- Brian O’Riordan (ORCID: https://orcid.org/0000-0002-7799-3843)
- Seán Connolly (ORCID: https://orcid.org/0000-0003-4884-861X)
- Sean Maher (ORCID: https://orcid.org/0000-0003-4724-5614)
- Carl Orr
- Ruth Prichard
Institutions
- University College Dublin (IE)
- St. Vincent's University Hospital (IE)
Publication Details
- Journal
- Endocrinology Diabetes and Metabolism Case Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1530/edm-25-0052
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00