An Fc-Engineered Glycomodified Antibody Supports Proinflammatory Activation of Immune Effector Cells and Restricts Progression of Breast Cancer
Assessment of Fc receptors and immune cells in breast cancer enables development of tailored engineering strategies for tumor-targeting monoclonal antibodies with enhanced immune-stimulating and anticancer attributes by combining glycoengineering and Fc mutations.
Authors
- Jennifer Trendell (ORCID: https://orcid.org/0000-0002-5517-0352)
- Daniel I. R. Spencer (ORCID: https://orcid.org/0000-0001-6386-0890)
- Alicia M. Chenoweth (ORCID: https://orcid.org/0000-0002-2736-9268)
- Shashi Jatiani (ORCID: https://orcid.org/0000-0003-0724-6583)
- Gabriel Osborn (ORCID: https://orcid.org/0000-0003-1439-1973)
- Amanda Gross (ORCID: https://orcid.org/0000-0002-1212-5498)
- James M. McDonnell (ORCID: https://orcid.org/0000-0001-9037-2980)
- Jitesh Chauhan (ORCID: https://orcid.org/0000-0002-3968-9234)
- Jelmar Quist (ORCID: https://orcid.org/0000-0003-3071-3776)
- Jack Cheeseman (ORCID: https://orcid.org/0000-0003-1112-217X)
- Syed Aleem Haider (ORCID: https://orcid.org/0000-0001-6685-5480)
- Anita Grigoriadis (ORCID: https://orcid.org/0000-0003-3434-201X)
- Benjamina Esapa (ORCID: https://orcid.org/0009-0003-4589-9697)
- Leonard Moise (ORCID: https://orcid.org/0000-0002-4410-865X)
- Alexandra McCraw (ORCID: https://orcid.org/0009-0008-2412-4389)
- Sophia N. Karagiannis (ORCID: https://orcid.org/0000-0002-4100-7810)
- Rebecca Adams (ORCID: https://orcid.org/0000-0002-8378-9048)
- Thomas Sénard (ORCID: https://orcid.org/0000-0001-5951-4127)
- Richard A. Gardner (ORCID: https://orcid.org/0000-0001-7601-7544)
- Anna M. Davies (ORCID: https://orcid.org/0000-0003-1498-1594)
- Anthony Cheung (ORCID: https://orcid.org/0000-0002-2988-2786)
- Kristina M. Ilieva (ORCID: https://orcid.org/0000-0002-6877-3793)
- Sophia Tsoka (ORCID: https://orcid.org/0000-0001-8403-1282)
- Judit Cserny (ORCID: https://orcid.org/0009-0002-7671-1143)
- Pablo Romero-Clavijo (ORCID: https://orcid.org/0000-0003-4380-3308)
- Roman Laddach (ORCID: https://orcid.org/0000-0002-0118-4548)
- Sheeba Irshad (ORCID: https://orcid.org/0000-0002-4419-7162)
- Katie Stoker (ORCID: https://orcid.org/0009-0002-7889-7164)
- Andrew N.J. Tutt (ORCID: https://orcid.org/0000-0001-8715-2901)
- Erin Suriawinata (ORCID: https://orcid.org/0009-0003-2379-515X)
- Blanca Navarro‐Llinas (ORCID: https://orcid.org/0009-0005-9383-9669)
- Melanie Grandits (ORCID: https://orcid.org/0000-0001-8143-8298)
- Lev Brown (ORCID: https://orcid.org/0009-0004-3554-024X)
- Astrid Clarke (ORCID: https://orcid.org/0009-0001-4539-1290)
Institutions
- King's College London (GB)
- Breast Cancer Now (GB)
- London Cancer (GB)
- Culham Science Centre (GB)
- London Institute for Mathematical Sciences (GB)
- Scientific Systems (United States) (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3174
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00