Flow Simulation Model for Arteriovenous Fistula/Graft

Background: Arteriovenous fistulas (AVFs) remain the preferred choice for dialysis vascular access. However, advancements in technologies that enhance maturation and minimize complications have been slow. To address this, we developed a flow circuit that simulates blood circulation through an AVF/AVG. This circuit can be utilized in research and development efforts to optimize AVFs. Methods: We created a parallel circuit using an ECMO machine circuit, mimicking the shunting effect of an AVF/AVG. Pressure and flow sensors were placed before and after the AVF/AVG, but they can also be added throughout the circuit depending on the specific information required. For example, measurements can include volume, pressure, resistance, turbulence, diameters, and so on, depending on the specifics being studied. Blood simulant is then returned to a reservoir, mimicking the right atrium, before being pumped again by the ECMO pump. [Figure 1] Results: This setup enabled us to test various scenarios that could impact the flow in an AVF and evaluate prototypes designed to reduce complications associated with AVFs. Conclusion: Innovation in AV access remains a dire need for hemodialysis patients. This setup can help obtain important data in the bench-top testing phases of new device development, enabling more accurate assumptions before advancing to an in vivo phase. Funding: Private Foundation SupportFigure 1. Illustration of the flow circuit used. Notice that pressure sensors can be moved around depending on the experimental scenario.