Clinical Pathology in Paracancer Tissues of Juxtaglomerular Cell Tumor

Introduction: Juxtaglomerular cell tumor (JGCT) is a rare, renin-secreting benign tumor that typically presents with symptoms such as hypertension and hypokalemi Case Description: This report details the case of a 31-year-old female patient admitted to our hospital with severe hypertension and blurred vision. She underwent hemodialysis due to worsening renal failure. The imaging findings revealed a hypovascular lump of the left kidney, initially suspected to be a malignant tumor. The patient subsequently underwent laparoscopic partial nephrectomy. Postoperative pathology confirmed the diagnosis of JGCT, meanwhile, the thromoticmicro angiopathy (TMA) pathological change caused by malignant hypertension of the paracancer tissues was observed as a consequence of long-term untreated hypertension, tending to pathological lesion chronicity that may account for creatinine levels persisted elevated and regular hemodialysis treatment is needed postoperatively, although her blood pressure was stable to normal level. Her renal function improved and be off dialysis 3 months after the operation. Discussion: This case highlights the diagnostic challenge of distinguishing JGCT from malignant renal tumors based on imaging alone. Unlike previously reported cases where renal function typically recovered postoperatively, this patient exhibited a unusual trajectory, underscoring the importance of regular health check-ups for early detection and management of renal lesions.