Correlation of Hypomagnesaemia with Calcineurin Inhibitor (CNI) Levels in Kidney Transplant Recipients: An Indian Cohort Study

Background: It is well known that electrolyte disturbances are common following solid oragan transplantation. Hypomagnesaemia is an electrolyte abnormality which is under recognized and under treated and has long term consequences following kidney transplantation. Hypomagnesemia has been reported to develop within the first few weeks following transplantation associated with the use of CNI, PPIs, diuretics etc. There is scarcity of data on prevalence of hypomagnesaemia immediately after transplant and its correlation with CNI levels. Methods: This was a single centre study in the Kidney Transplant unit of ILBS Vasant Kunj, New Delhi between Jan 2023 to July 2024 Results: During the above period of 18 months, 120 patients underwent kidney transplant of which 14 were DDKT and 106 were LDKT. The median age of patients was 37 years (IQR with 78 percent male predominance). The incidence of hypomagnesaemia was 15 & 90 percent after 10th day & 30th day post transplant. The median time to presentation was 7-10 days from transplant. There was no relation to CNI levels as 108 of 120 had hypomagnesemia inspite of normal or low Tacrolimus level at the time of detection. 64 patients required IV supplementation and 44 required oral supplementation Conclusion: Hypomagnesemia is common in renal transplant recipients. The incidence of hypomagnesemia was strikingly high in the study. There was no correlation with the occurrence of hypomagnesemia with CNI levels