Rapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-daily Oral Paltusotine Treatment
IGF-I normalized in significantly more patients with uncontrolled acromegaly treated with paltusotine vs placebo. Paltusotine was associated with rapid, sustained IGF-I reduction, significant symptom improvement and stable or reduced pituitary tumor size and was well tolerated.
Authors
- Erika Hubina
- Pouneh K. Fazeli (ORCID: https://orcid.org/0000-0003-1731-2927)
- Raquel S. Jallad
- Maria Fleseriu (ORCID: https://orcid.org/0000-0001-9284-6289)
- Beibei Hu (ORCID: https://orcid.org/0000-0001-7317-6873)
- Alan Krasner (ORCID: https://orcid.org/0009-0005-5658-3246)
- Christian J. Strasburger (ORCID: https://orcid.org/0000-0001-7905-7357)
- Mônica R. Gadelha (ORCID: https://orcid.org/0000-0002-9250-3558)
- Martin Bidlingmaier (ORCID: https://orcid.org/0000-0002-4681-6668)
- César Luiz Boguszewski (ORCID: https://orcid.org/0000-0001-7285-7941)
- Beatriz Santana Soares
- Атанаска Еленкова (ORCID: https://orcid.org/0000-0001-9821-4952)
- R. Scott Struthers
- Beverly M. K. Biller (ORCID: https://orcid.org/0000-0003-4359-4622)
- Peter Trainer (ORCID: https://orcid.org/0000-0003-0146-3835)
- Yining Zhao (ORCID: https://orcid.org/0009-0006-4828-5254)
- Peter J. Snyder
- Alessandra Casagrande
Institutions
- Universidade Federal de Minas Gerais (BR)
- Oregon Health & Science University (US)
- University of Pittsburgh (US)
- Universidade de São Paulo (BR)
- Military Hospital (PK)
- Medical University of Sofia (BG)
- LMU Klinikum (DE)
- Massachusetts General Hospital (US)
- Universitätsklinikum Erlangen (DE)
- Central Military Hospital (NL)
- Crinetics Pharmaceuticals (United States) (US)
- Hospital Universitário Clementino Fraga Filho (BR)
- Universidade Federal do Paraná (BR)
- Charité - Universitätsmedizin Berlin (DE)
- University of Pennsylvania (US)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1210/clinem/dgaf579
- Citations
- 3
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- Pfizer
- Novo Nordisk