Economic Evaluation of a Naloxone Distribution and Training via a State-Level Opioid Overdose Prevention Program, New York State, April 2023 to March 2025

Naloxone is efficacious at reversing opioid overdoses and appears efficient in mathematical models of its use. State-level, field-based data on naloxone administrations in the New York State Department of Health's Opioid Overdose Prevention Program (OOPP) network, as well as OOPP budgetary data, informed an economic evaluation of these statewide efforts. Results indicated high levels of lives saved, years of life saved, and economic benefits across the time-period April 2023 to March 2025. Given the substantial beneficial impact of naloxone provision and training via the New York OOPP network, continued investment is warranted until all unmet needs are addressed and recent downward trajectories in fatal overdoses are continued.