Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ‐Mediated Immunotherapy (Adv. Mater. 42/2025)
IFNβ-Mediated Immunotherapy In their Research Article (DOI: 10.1002/adma.202419870), Yufei Xia, Zhiqiang Lin, Fuping You, and co-workers identify a nanomaterial calcium phosphate-containing liposome (NanoCa), which exhibits a loose internal structure and an amorphous crystalline composition, enabling rapid calcium ion release via the lysosomal pathway. NanoCa activates IFNβ in bone marrow-derived dendritic cells, serving as a “bridge” that links antigen presentation to anti-tumor effects across various tumor models.
Authors
- Fuping You
- Chuanda Zhu (ORCID: https://orcid.org/0000-0002-3774-747X)
- Yunfei Xie (ORCID: https://orcid.org/0000-0002-2758-9236)
- Dan Lü (ORCID: https://orcid.org/0000-0002-3000-5094)
- Zhiqiang Lin (ORCID: https://orcid.org/0000-0003-1834-2060)
- Yu Sun (ORCID: https://orcid.org/0000-0003-2066-5053)
- Xuefei Guo (ORCID: https://orcid.org/0000-0002-9590-8235)
- Yufei Xia (ORCID: https://orcid.org/0000-0003-1215-6128)
- Yujie Luo
Institutions
- Peking University (CN)
- Institute of Process Engineering (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/adma.70844
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00