Lamotrigine-induced DRESS Syndrome in an Epileptic Patient: A Rare but Life-threatening Adverse Drug Reaction

An 18-year-old female patient with a known diagnosis of epilepsy presented to the emergency department with a one-month history of generalized rash accompanied by progressively worsening fever over the last ten days.Based on clinical suspicion of drug-induced hypersensitivity reaction, the patient was admitted to the dermatology department and subsequently referred to our neurology clinic for evaluation of potential antiseizure drug-associated adverse effects.The patient had a one-year history of generalized onset tonic-clonic seizures, with a baseline frequency of approximately 10 episodes per month.Her antiseizure treatment consisted of levetiracetam (LEV) 1000 mg/day, initiated three months prior to evaluation.Due to persistent seizure activity, LTG was added six weeks before admission.Following this adjustment, her seizure frequency had decreased to three episodes per month.