Evaluation of Polygenic Risk Scores for a Possible Genetic Basis of the Inverse Association Between Cancer and Cognitive Decline
Though not conclusive, the direction of the association between PRS cancer and fluid intelligence was consistent with our a priori hypothesis that cancer risk variants would decrease cognitive decline. The association pattern with HLA-related variants suggests potential relevance of immune surveillance for the inverse association between dementia and cancer.
Authors
- M. Maria Glymour (ORCID: https://orcid.org/0000-0001-9644-3081)
- Jovia L. Nierenberg (ORCID: https://orcid.org/0000-0003-2376-6714)
- Kun Ping Lu (ORCID: https://orcid.org/0000-0002-0734-1567)
- John S. Witte (ORCID: https://orcid.org/0000-0003-0146-1434)
- Scott C. Zimmerman (ORCID: https://orcid.org/0000-0002-4431-6520)
- Dorothy M. Chen (ORCID: https://orcid.org/0009-0004-2597-9064)
- Kaitlin N. Swinnerton (ORCID: https://orcid.org/0000-0002-7429-9960)
- Rebecca E. Graff (ORCID: https://orcid.org/0000-0003-0316-8303)
- Sarah F. Ackley (ORCID: https://orcid.org/0000-0003-0181-6063)
- Jingxuan Wang (ORCID: https://orcid.org/0000-0002-9387-0480)
- Peter Buto (ORCID: https://orcid.org/0000-0001-5052-6009)
- Fanny M. Elahi (ORCID: https://orcid.org/0000-0003-4663-4992)
- Monica Ospina‐Romero (ORCID: https://orcid.org/0000-0001-7719-7284)
Institutions
- Boston University (US)
- Western University (CA)
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- VA Boston Healthcare System (US)
- University Memory and Aging Center (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer Disease & Associated Disorders
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1097/wad.0000000000000696
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00