Effects of Extended‐Release Methylphenidate on Dopamine and Norepinephrine Transporters in Adults With Attention‐Deficit/Hyperactivity Disorder: A Longitudinal Dual‐Tracer <scp>PET</scp> Study
MPH simultaneously reduced DAT and NET binding in ADHD, enhanced dopamine and norepinephrine transmission, and improved cognitive function. The differential occupancy of DAT and NET suggests distinct contributions to the therapeutic effects of MPH.
Authors
- Wakako Ito
- Keisuke Takahata (ORCID: https://orcid.org/0000-0002-0884-4924)
- Hironobu Endo
- Masaki Oya
- Naomi Kokubo (ORCID: https://orcid.org/0009-0008-8748-4701)
- Shin Kurose (ORCID: https://orcid.org/0000-0001-8355-4946)
- Genichi Sugihara (ORCID: https://orcid.org/0000-0002-0060-0538)
- Makoto Higuchi (ORCID: https://orcid.org/0000-0002-9190-7235)
- Hidehiko Takahashi (ORCID: https://orcid.org/0000-0002-5102-1982)
- Yuko Kataoka (ORCID: https://orcid.org/0000-0001-7584-1005)
- Yuhei Takado (ORCID: https://orcid.org/0000-0001-7484-8424)
- Masanori Ichihashi
- Masaaki Shimizu (ORCID: https://orcid.org/0000-0002-2014-0161)
- Kiwamu Matsuoka (ORCID: https://orcid.org/0000-0003-3263-0958)
- Chie Seki (ORCID: https://orcid.org/0000-0002-3222-7125)
- Manabu Kubota (ORCID: https://orcid.org/0000-0001-9507-1845)
- Kosei Hirata (ORCID: https://orcid.org/0009-0007-9027-9277)
- Kenji Tagai (ORCID: https://orcid.org/0000-0002-4551-1491)
- Soichiro Kitamura (ORCID: https://orcid.org/0000-0002-3190-8068)
- Motoaki Nakamura (ORCID: https://orcid.org/0000-0003-2830-3049)
- Shunsuke Takagi
- Nobumasa Kato
Institutions
- SHOWA Medical University (JP)
- Tokyo Medical and Dental University (JP)
- Keio University (JP)
- Kyoto University (JP)
- Neuropsychiatric Research Institute (US)
- National Institutes for Quantum Science and Technology (JP)
- Bio-oriented Technology Research Advancement Institution (JP)
- Japan Research Institute (JP)
- Institute of Science Tokyo (JP)
- Nara Medical University (JP)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1111/pcn.13911
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kowa Company
- Daiichi-Sankyo
- Eisai
- Meiji Seika Pharma
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology