BDNF Loaded Amino Acid‐Catecholamine Hybrid Nanoparticles as Curative Agents Against Cognitive Decline in Alzheimer's Disease (Small 42/2025)

Alzheimer's Disease BDNF-loaded amino acid–catecholamine hybrid nanoparticles (B-EDTNPs) are capable of crossing the blood–brain barrier (BBB) to efficiently deliver BDNF. These nanoparticles inhibit Aβ fibrillization, promote amyloid plaque clearance, reduce oxidative stress, and protect neuronal cells from fibril-induced damage. In SH-SY5Y neuroblastoma cells, B-EDTNPs significantly improve cell viability against FF and Aβ (1-42) toxicity. Promising outcomes in AD mouse model are shown by effectively reducing amyloid plaque accumulation, suppress inflammatory markers like NF-κB and TNF-α, and restore cognitive functions. More in article number 2411701, Ashok Kumar Datusalia, Jiban Jyoti Panda, and co-workers.