MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk
We developed fully automated methods for quantifying diffusion tensor image analysis along the perivascular space (DTI-ALPS) and blood oxygen level-dependent cerebrospinal fluid (BOLD-CSF) coupling. Three CSF dynamics markers-BOLD-CSF coupling, DTI-ALPS, and choroid plexus (CP) volume-were predictive of incident dementia, whereas PVS volume was not. Magnetic resonance imaging proxies of CSF dynamics markers were associated with cardiovascular injury. CP volume and DTI-ALPS mediated the associations of both white matter hyperintensities and diabetes with dementia.
Authors
- Peiyu Huang (ORCID: https://orcid.org/0000-0003-4226-9369)
- Hui Hong (ORCID: https://orcid.org/0000-0002-8807-7859)
- Hugh S. Markus (ORCID: https://orcid.org/0000-0002-9794-5996)
- Yeerfan Jiaerken (ORCID: https://orcid.org/0000-0002-0734-4012)
- Yutong Chen (ORCID: https://orcid.org/0000-0001-8024-8775)
- Dan Tozer
Institutions
- University of Cambridge (GB)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70699
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- Department of Health and Social Care
- University of Cambridge
- Cambridge University Hospitals