Primordial germ cell specification and early developmental cell states in Pacific oyster
We identified a suite of candidate genes that can be explored for their role in oyster PGC specification and advance efforts to develop methods to achieve reproductive sterility via germ cell disruption in cultured shellfish. In addition, this effort produced a transcriptional atlas of early developmental cell states in bivalve embryos, providing a wealth of information on genes contributing to other important developmental processes, such as tissue differentiation and shell production. These data represent the earliest developmental stages examined via single-cell RNA sequencing in a lophotrochozoan.
Authors
- Lauren M. Saunders (ORCID: https://orcid.org/0000-0003-4377-4252)
- Cole Trapnell (ORCID: https://orcid.org/0000-0002-8105-4347)
- Steven Roberts (ORCID: https://orcid.org/0000-0001-8302-1138)
- J. Adam Luckenbach (ORCID: https://orcid.org/0000-0002-9776-0756)
- Lauren E. Vandepas (ORCID: https://orcid.org/0000-0001-7594-9171)
- Mackenzie Gavery (ORCID: https://orcid.org/0000-0001-5010-3399)
- Brent Vadopalas (ORCID: https://orcid.org/0000-0002-1791-2095)
Institutions
- NOAA National Marine Fisheries Service (US)
- National Oceanic and Atmospheric Administration (US)
- University of Washington (US)
- Heidelberg University (DE)
- NOAA National Marine Fisheries Service Northwest Fisheries Science Center (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s12864-025-12122-7
- Primary Topic
- Marine Bivalve and Aquaculture Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Oceanic and Atmospheric Administration
- Washington Sea Grant, University of Washington
- Northwest Fisheries Science Center