Intestinal LKB1 Loss Drives a Premalignant Program Along the Serrated Cancer Pathway
Heterozygous loss of LKB1 pushes intestinal cells into a chronic regenerative state, which is amplified on loss of heterozygosity. Lkb1 deficiency thereby generates fertile ground for serrated colorectal cancer formation in the intestine, potentially explaining the increased cancer risk observed in PJS.
Authors
- Roy Straver (ORCID: https://orcid.org/0000-0002-8031-1735)
- Joep Sprangers
- Carol Jamieson (ORCID: https://orcid.org/0000-0001-9160-0746)
- Despina Xanthakis
- Jelte van der Vaart (ORCID: https://orcid.org/0000-0002-4126-8420)
- Susanna Plugge
- Madelon M. Maurice (ORCID: https://orcid.org/0000-0001-6885-5361)
- Alessandra Merenda (ORCID: https://orcid.org/0009-0002-3935-0713)
- F.C.R. Holstege
- Folkert H.M. Morsink (ORCID: https://orcid.org/0000-0003-2599-4040)
- G. J. A. Offerhaus
- H. Ma (ORCID: https://orcid.org/0000-0002-8916-6220)
- Tito Candelli (ORCID: https://orcid.org/0000-0003-2440-6032)
- T Margaritis
- A. Keijzer
- Wendy W.J. de Leng (ORCID: https://orcid.org/0000-0003-2911-6018)
- J. de Ridder
- K B W Stroot
Institutions
- University Medical Center Utrecht (NL)
- Oncode Institute (NL)
- Princess Máxima Center (NL)
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1053/j.gastro.2025.07.041
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47