Application of a French cattle pangenome, from structural variant discovery to association studies on key phenotypes
Our study provides new insights into the genetic diversity of 14 French dairy and beef breeds and highlights the utility of pangenome graphs in capturing structural variation. The identified SV associated with stature highlights the importance of integrating SVs into GWAS for a more comprehensive understanding of complex traits.
Authors
- Mekki Boussaha (ORCID: https://orcid.org/0000-0002-5432-4604)
- Christine Gaspin (ORCID: https://orcid.org/0000-0003-0304-5186)
- Carole Iampietro (ORCID: https://orcid.org/0000-0002-8148-4785)
- Clémentine Escouflaire (ORCID: https://orcid.org/0000-0003-3586-9761)
- Didier Boichard (ORCID: https://orcid.org/0000-0003-0361-2961)
- Amandine Suin
- Maulana M. Naji (ORCID: https://orcid.org/0000-0002-3264-2708)
- Laurence Drouilhet (ORCID: https://orcid.org/0000-0003-0407-9820)
- Camille Eché (ORCID: https://orcid.org/0000-0002-1460-0969)
- Camille Marcuzzo
- Clément Birbes (ORCID: https://orcid.org/0000-0002-8360-6512)
- Marie-Pierre Sanchez (ORCID: https://orcid.org/0000-0002-1371-5342)
- Cécile Grohs (ORCID: https://orcid.org/0000-0002-3563-8966)
- Christophe Klopp (ORCID: https://orcid.org/0000-0001-7126-5477)
- Sébastien Fritz (ORCID: https://orcid.org/0000-0002-3378-1048)
- Cécile Donnadieu (ORCID: https://orcid.org/0000-0002-5041-6843)
- Denis Milan
- Gwenola Tosser-Klopp
- Valentin Sorin
Institutions
- École Nationale Vétérinaire de Toulouse (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- AgroParisTech (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Génétique Physiologie et Systèmes d'Elevage (FR)
Publication Details
- Journal
- Genetics Selection Evolution
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s12711-025-01012-x
- Citations
- 2
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Agence Nationale de la Recherche
- Région Occitanie Pyrénées-Méditerranée