Studying nasal aerosols in microfluidics: opportunities and challenges

Accurate modeling of the nasal airway microenvironment, including airflow and the associated mechanical stresses, is necessary to replicate the realistic interaction between aerosol particles and their surrounding geometries as they traverse complex respiratory pathways through the nose. Novel measures and techniques to complement organ-on-chip devices will be critical to replicating the transport and deposition of aerosols in realistic nasal airways. Future research may focus on the development of more powerful tools that enable high-throughput examinations of nasal aerosols, delivering simultaneous insights into particle behavior and tissue responses.