Kaempferols from Echinacea purpurea demonstrate anti-cancer potential by targeting anexelekto in breast cancer therapy using chemoinformatics approach
In silico studies show that E. purpurea-derived compounds, especially Kaempferol 3-o-beta-d-glucopyranosyl-7-o-alpha-L-rhamnopyranoside, have better inhibitory potential against AXL and better pharmacokinetic profiles when compared with Foretinib. These compounds are thus proposed as novel AXL inhibitors for the treatment of breast cancer. Further, in vivo studies are needed to confirm the potency of the studied compounds.
Authors
- Toheeb A. Balogun (ORCID: https://orcid.org/0000-0002-6267-425X)
- Abdulwasiu Ibrahim (ORCID: https://orcid.org/0000-0003-3456-005X)
- Kayode Yomi Raheem (ORCID: https://orcid.org/0000-0001-7975-9228)
- Timothy Oluwatimileyin Ayeni (ORCID: https://orcid.org/0000-0002-7442-2228)
- Daniel O. Nwankwo (ORCID: https://orcid.org/0000-0002-1179-1536)
- Damilola S. Bodun (ORCID: https://orcid.org/0000-0003-3440-8015)
- Ayomide Oluwadarasimi Adebesin (ORCID: https://orcid.org/0000-0003-3978-9558)
- Opeyemi C. De Campos (ORCID: https://orcid.org/0000-0001-9094-5670)
- Abass Abdulateef Ohilebo (ORCID: https://orcid.org/0000-0002-6509-9262)
- Md. Ahad Ali (ORCID: https://orcid.org/0000-0002-9200-7669)
- Saviour God’swealth Usin (ORCID: https://orcid.org/0000-0003-0759-1862)
- O. S. Awotunde (ORCID: https://orcid.org/0000-0002-8109-2343)
- Siham Lakrikh (ORCID: https://orcid.org/0000-0003-0325-3639)
- Abdulsamad Omotayo Aiyelabegan (ORCID: https://orcid.org/0000-0001-7772-753X)
- Cornelius Ayodeji Aboderin
- Anas Haruna Ruggah (ORCID: https://orcid.org/0000-0001-5372-6567)
Institutions
- University of Notre Dame (US)
- Panacea Biotec (India) (IN)
- Fountain University (NG)
- University of San Diego (US)
- University of Ibadan (NG)
- Covenant University (NG)
- University of North Dakota (US)
- Adekunle Ajasin University (NG)
- University of Cross River State (NG)
- University of Kigali (RW)
- Osun State University (NG)
- University of California San Diego (US)
- Université Sultan Moulay Slimane (MA)
- Rwanda Biomedical Center (RW)
- Ambrose Alli University (NG)
- Usmanu Danfodiyo University (NG)
- University of Rajshahi (BD)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1007/s12672-025-03541-9
- Primary Topic
- Nigella sativa pharmacological applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université Sultan Moulay Slimane