Invisible influencers: the tumor microbiome’s impact on immunotherapy in colorectal cancer (CRC)
The tumor microbiome shapes CRC immunotherapy efficacy by modulating immune evasion and TME dynamics. Targeted interventions like FMT and probiotics show promise in enhancing ICI responses, but challenges include microbial variability, safety concerns, and ethical considerations. Future research should prioritize personalized microbiome profiling and standardized protocols to optimize therapeutic outcomes and overcome resistance in CRC.
Authors
- Pouria Salajegheh
- J Bethanney Janney (ORCID: https://orcid.org/0000-0001-6367-1336)
- S. Renuka Jyothi
- Rasim M Salih
- D. Polatova (ORCID: https://orcid.org/0000-0001-8128-2553)
- Mohaned Adil (ORCID: https://orcid.org/0009-0000-9607-0684)
- Gurjant Singh (ORCID: https://orcid.org/0000-0002-7421-8868)
- Ali Fawzi Al-Hussainy
- Hayder Naji Sameer
- Thabit Moath Omar (ORCID: https://orcid.org/0009-0006-0057-7178)
- Priya Priyadarshini Nayak (ORCID: https://orcid.org/0009-0001-8421-3630)
Institutions
- Chandigarh University (IN)
- Jain University (IN)
- Al Noor Hospitals (AE)
- Siksha O Anusandhan University (IN)
- Thi Qar University (IQ)
- Kerman University of Medical Sciences (IR)
- Islamic Azad University of Farahan (IR)
- Ahl Al Bayt University (IQ)
- Al-Nisour University College (IQ)
- Institute of Medical Sciences and Sum Hospital (IN)
- University of Kerbala (IQ)
- Tashkent Pediatric Medical Institute (UZ)
- Republican Scientific and Practical Center of Neurology and Neurosurgery (BY)
- Sathyabama Institute of Science and Technology (IN)
- Al-Farahidi University
Publication Details
- Journal
- Expert Review of Anticancer Therapy
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1080/14737140.2025.2579656
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05