Breaking the cycle of psoriasis: the role for early intervention
Psoriasis is typically managed via a ‘Staircase’ approach, slowly escalating treatment from topical treatments to biologics, often delaying effective intervention for several years. Recent evidence supports an ‘Elevator’ approach, advocating for early use of systemic therapies to improve long-term outcomes, prevent disease memory and reduce comorbidities. A paradigm shift from reactive disease-centred care may improve long-term outcomes of psoriasis patients.
Authors
- Thomas Graier (ORCID: https://orcid.org/0000-0002-3007-7776)
- Su M. Lwin (ORCID: https://orcid.org/0000-0002-3325-3675)
- Christopher E.M. Griffiths (ORCID: https://orcid.org/0000-0001-5371-4427)
Institutions
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Medical University of Graz (AT)
- University of Manchester (GB)
- Thomas Foundation (AU)
- King's College Hospital NHS Foundation Trust (GB)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-10-19
- DOI
- https://doi.org/10.1093/bjd/ljaf403
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Eli Lilly and Company
- Sanofi
- Amryt Pharma