Mechanical stress promotes synovial inflammation and osteoarthritis development via the NF-κB p52/IL-6 signalling pathway
Mechanical stress drives TMJOA synovial inflammation via integrin αIIbβ3/NF-κB-mediated IL-6 secretion, linking biomechanical perturbations to cartilage degradation. Targeting this pathway may offer novel therapeutic strategies for TMJOA.
Authors
- Jiashun Wu
- Yu Liu (ORCID: https://orcid.org/0000-0001-9184-5970)
- Huanzhong Ji
- Guangsen Zheng
- Wei Sun
- Suxun Pan
- Yi Shen (ORCID: https://orcid.org/0009-0004-7758-6633)
Institutions
- Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-10-19
- DOI
- https://doi.org/10.1093/rheumatology/keaf553
- Citations
- 1
- Primary Topic
- Temporomandibular Joint Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.14