Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2

Authors

Xiyue Li (ORCID: https://orcid.org/0000-0001-7331-8544)
Jiehong Wang
Naiyan Lu (ORCID: https://orcid.org/0000-0001-9778-2819)
Yue Hao (ORCID: https://orcid.org/0000-0002-4725-6084)
Xun Wang (ORCID: https://orcid.org/0000-0001-7269-0969)
Ke Wang (ORCID: https://orcid.org/0000-0002-2824-1047)
Zhu Xue (ORCID: https://orcid.org/0009-0006-0650-0913)
Jiaojiao Chen (ORCID: https://orcid.org/0000-0002-9041-0307)
Hong Shu (ORCID: https://orcid.org/0000-0002-2844-8347)
Shu Li (ORCID: https://orcid.org/0000-0003-2976-7515)
You Shu
Jing Fang (ORCID: https://orcid.org/0009-0007-5573-7025)
C. Xu (ORCID: https://orcid.org/0000-0002-9021-6731)

Institutions

Jiangnan University (CN)
Guangxi Medical University (CN)
Jiangsu Second Normal University (CN)
Zhejiang Cancer Hospital (CN)
Wuxi Fourth People's Hospital (CN)
Nanjing Medical University (CN)

Publication Details

Journal: Cellular Oncology
Published: 2025-10-22
DOI: https://doi.org/10.1007/s13402-025-01107-z
Primary Topic: Ubiquitin and proteasome pathways
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Jiangsu Commission of Health
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province

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article

Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2

Xiyue Li, Jiehong Wang, Naiyan Lu, Yue Hao et al.

Oct 22, 2025

Cellular Oncology

Ubiquitin and proteasome pathways

article

Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2

Xiyue Li, Jiehong Wang, Naiyan Lu, Yue Hao, Xun Wang, Ke Wang, Zhu Xue, Jiaojiao Chen, Hong Shu, Shu Li, You Shu, Jing Fang, C. Xu

October 22, 2025article en

Abstract

No abstract available for this paper.

Cellular OncologyVol. 48(6)

Jiangnan University (CN), Guangxi Medical University (CN), Jiangsu Second Normal University (CN), Zhejiang Cancer Hospital (CN), Wuxi Fourth People's Hospital (CN), Nanjing Medical University (CN)

Jiangsu Commission of Health, National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province

Openalex Percentile: Top 73%

Ubiquitin and proteasome pathways

DOI Open Access PDF OpenAlex

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