The nuclear receptor REV-ERBα regulates coumarin hepatotoxicity via DBP-dependent repression of CYP2A5 in mice
The knockout of <i>Rev-erbα</i> significantly reduces the hepatotoxicity of coumarin by modulating CYP2A5. This research underscores the potential of targeting the REV-ERBα/CYP2A5 axis as a novel strategy for reducing coumarin-induced hepatotoxicity.
Authors
- Jingqi Li (ORCID: https://orcid.org/0000-0001-8763-5452)
- Yutong Chen (ORCID: https://orcid.org/0000-0001-6279-828X)
- Danyi Lu
- Haishan Xia
- Jinyi Wang (ORCID: https://orcid.org/0000-0002-1371-6310)
- Zhiqiang Zhao
- Yongbin Tong
- Qi Zhang (ORCID: https://orcid.org/0000-0003-0692-1815)
- Yuyu Liu (ORCID: https://orcid.org/0000-0002-4814-8616)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Medical College (CN)
- Guangdong Pharmaceutical University (CN)
- Guangdong Ocean University (CN)
Publication Details
- Journal
- Expert Opinion on Drug Metabolism & Toxicology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1080/17425255.2025.2577675
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00