Loss of the Y Chromosome in Oral Potentially Premalignant Disorders Predicts Malignant Progression: An Integrative Cross‐Species Multi‐Cohort Bioinformatic Study
LOY/EDY can be detected in OPMD and promotes malignant progression by altering oncogenic signaling and epithelial cell interactions. LOY/EDY may serve as both a diagnostic biomarker and a therapeutic target, improving clinical management and patient outcomes.
Authors
- Cristina Conde‐López (ORCID: https://orcid.org/0000-0001-9928-790X)
- Jos B. Poell (ORCID: https://orcid.org/0000-0003-1776-3779)
- Ina Kurth (ORCID: https://orcid.org/0000-0001-9261-5165)
- Jochen Heß (ORCID: https://orcid.org/0000-0003-3493-1711)
- Tuula Anneli Salo (ORCID: https://orcid.org/0000-0001-6039-0088)
- Ruud H. Brakenhoff (ORCID: https://orcid.org/0000-0003-3251-5378)
- Rui Han
Institutions
- University of Helsinki (FI)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- University Hospital Heidelberg (DE)
- Heidelberger Institut für Radioonkologie (DE)
- National Center for Tumor Diseases (DE)
- Cancer Center Amsterdam (NL)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Oulu University of Applied Sciences (FI)
- Vrije Universiteit Amsterdam (NL)
- University of Oulu (FI)
Publication Details
- Journal
- Head & Neck
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1002/hed.70070
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Krebsforschungszentrum
- China Scholarship Council
- Narodowa Agencja Wymiany Akademickiej