CV2/CRMP5 antibodies are specifically associated with parenchymal neurosyphilis: a retrospective cohort study
Our study identifies a strong association between CV2/CRMP5 antibodies and p-NS. Screening for these antibodies is recommended for p-NS patients, especially those with high serum TRUST titers and intrathecal immunoglobulin synthesis, as they may represent a subgroup with distinct immunopathological mechanisms.
Authors
- Yangyi He (ORCID: https://orcid.org/0000-0003-0792-193X)
- Yan Ren
- Jierui Wang (ORCID: https://orcid.org/0000-0002-1755-7169)
- Minjin Wang (ORCID: https://orcid.org/0000-0001-7989-0330)
- Bin Yang (ORCID: https://orcid.org/0000-0002-0275-3722)
- Yike Huang (ORCID: https://orcid.org/0000-0002-8450-2387)
- Nan Zhang (ORCID: https://orcid.org/0000-0001-6518-2501)
- Dongdong Li (ORCID: https://orcid.org/0000-0002-0290-6485)
- Meng Tang
- Yang Su
- Xingbo Song (ORCID: https://orcid.org/0009-0000-3946-584X)
- Qian Niu (ORCID: https://orcid.org/0009-0006-7181-8362)
- Lan Luo
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Public Health Clinical Center of Chengdu (CN)
- Shanghai Clinical Research Center (CN)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- QJM
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1093/qjmed/hcaf253
- Citations
- 1
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16