MALAT1’s m6A Modification by METTL3 Promotes Pyroptosis and Inflammation in Sepsis-Induced Acute Kidney Injury in Mice
METTL3 promotes pyroptosis in SAKI by enhancing the m6A modification of MALAT1. Targeting the METTL3/MALAT1 axis may provide a potential therapeutic strategy for SAKI by mitigating renal inflammation and cell death.
Authors
- Gao Deng
- Yanfei Ma (ORCID: https://orcid.org/0000-0002-4887-3156)
- Haidong Wei (ORCID: https://orcid.org/0000-0002-6623-5502)
- Pengwei Guo
- Lingling Li (ORCID: https://orcid.org/0000-0002-7280-9592)
- Yan‐Hong Tan
- Yunxia Gong
Institutions
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s530214
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81