Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response

Here, we show that IPA isoforms are a novel source of microproteins, and we reveal the novel paradigm of miP-5'UTR-IPA genes that produce both a canonical full-length mRNA and a microprotein-coding IPA isoform.

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Publication Details

Journal
Genome biology
Published
2025-10-23
DOI
https://doi.org/10.1186/s13059-025-03829-7
Primary Topic
RNA Research and Splicing
Type
article
Field-Weighted Citation Impact
0.00

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article

Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response

Sophie Michallet, Pierre Gestraud, Mandy Cadix, Jean‐Baptiste Claude et al.
Genome biology
RNA Research and Splicing
article

Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response

Sophie Michallet, Pierre Gestraud, Mandy Cadix, Jean‐Baptiste Claude, Amélie Heneman-Masurel, Alina Chakraborty, L.H. Tessier, Nicolas Servant, Béatrice Eymin, Subhadarsini Sahoo, Virginie Raynal, Sonia Lameiras, Céline M. Labbé, Hussein Mortada, Sylvain Baulande, Iris Tanaka, Alexandre Devaux, Stéphan Vagner, Nicolas Fontrodona, Didier Auboeuf, Marc Deloger, Martin Dutertre, Quentin Fouilleul
article en

Abstract

Here, we show that IPA isoforms are a novel source of microproteins, and we reveal the novel paradigm of miP-5'UTR-IPA genes that produce both a canonical full-length mRNA and a microprotein-coding IPA isoform.

Genome biologyVol. 26(1)
Université Claude Bernard Lyon 1 (FR), École Normale Supérieure de Lyon (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Paris Sciences et Lettres (FR), Université Paris-Saclay (FR), La Ligue Contre le Cancer (FR), Institut Curie (FR), Université Grenoble Alpes (FR)
Equipex, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Fondation ARC pour la Recherche sur le Cancer, Ministère de l'Enseignement Supérieur et de la Recherche, Institut National Du Cancer, Direction Générale de l’offre de Soins
Openalex Percentile: Top 73%
RNA Research and Splicing
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