Molecular Mechanisms of Exosomes From Human iPSC‐Cardiomyocytes and Mesenchymal Stem Cells in Restoring the Injured Myocardium
These findings highlight the complementary roles of iCM-Exo and MSC-Exo in myocardial repair with shared pathways contributing to baseline improvement and distinct pathways driving differences in efficacy. Future studies investigating the potential of combinatorial approaches may provide further insights into optimizing the therapeutic outcomes for patients with heart failure.
Authors
- Nathan Bayardo (ORCID: https://orcid.org/0000-0001-8574-767X)
- Phillip C. Yang (ORCID: https://orcid.org/0000-0002-6274-895X)
- Eileen Tzng (ORCID: https://orcid.org/0000-0002-7513-9192)
- Mihoko V. Bennett (ORCID: https://orcid.org/0000-0002-3449-9538)
- Michael Snyder (ORCID: https://orcid.org/0000-0003-0784-7987)
- Joseph C. Wu (ORCID: https://orcid.org/0000-0002-6068-8041)
- Hirotaka Ieki (ORCID: https://orcid.org/0000-0002-6252-6134)
- Connor O’Brien (ORCID: https://orcid.org/0000-0002-2325-8317)
- Hiroyuki Takashima (ORCID: https://orcid.org/0000-0003-1077-9188)
- Gentaro Ikeda (ORCID: https://orcid.org/0000-0003-4019-8990)
- Nirmal Vadgama (ORCID: https://orcid.org/0000-0001-6226-3867)
- Jennifer Lyons
Institutions
- University of California, San Francisco (US)
- Cardiovascular Institute of the South (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1161/jaha.124.037005
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81