Heart Failure With Preserved Ejection Fraction and Lower Natriuretic Peptide: Clinical Characteristics and Change in Natriuretic Peptide Levels
More than half of patients with HF with preserved ejection fraction had NT-proBNP <300 pg/mL at baseline. Patients with mild elevations in NT-proBNP may progress to overt elevations over time, accompanied by cardiac deterioration and adverse outcomes.
Authors
- Nobuhiro Yaoita (ORCID: https://orcid.org/0000-0003-2667-8031)
- Makoto Higuchi (ORCID: https://orcid.org/0000-0002-3934-5810)
- Koji Kumagai (ORCID: https://orcid.org/0000-0003-1880-1175)
- Makoto Nakagawa (ORCID: https://orcid.org/0000-0001-8243-7705)
- Tomoko Kobayashi (ORCID: https://orcid.org/0000-0002-2226-6702)
- Satoru Horiguchi
- Ichiro Tsuji (ORCID: https://orcid.org/0000-0001-5626-0184)
- Masayuki Chida (ORCID: https://orcid.org/0000-0001-8502-1502)
- Yutaka Minatoya
- Juntaro Kaneko
- Akira Sato (ORCID: https://orcid.org/0000-0001-7015-4038)
- Masaki Hirose (ORCID: https://orcid.org/0000-0003-1470-2460)
- Masahiko Hayashi (ORCID: https://orcid.org/0000-0002-1716-6686)
- Mitsumasa Fukuchi
- Noriko Onoue
- Hiroaki Shimokawa (ORCID: https://orcid.org/0000-0001-7534-4826)
- Shigeto Namiuchi (ORCID: https://orcid.org/0000-0002-2368-9897)
- Satoshi Yasuda (ORCID: https://orcid.org/0000-0002-7470-5236)
- Soichiro Tadaki
- Hirotaro Ogino
- Kazuki Noda (ORCID: https://orcid.org/0009-0000-5931-6139)
- Yoshinobu Ikeno
- Hisao Ogawa (ORCID: https://orcid.org/0000-0003-2532-6130)
- Nobuyuki Shiba
- Satoshi Miyata (ORCID: https://orcid.org/0000-0003-2400-7525)
- Chiharu Saga
- Tomoyasu Yahagi
- Makoto Morita (ORCID: https://orcid.org/0000-0003-2392-9368)
- Nobumasa Ishide
- Masakazu Washio (ORCID: https://orcid.org/0000-0002-6839-8233)
- Syoichi Sato
- Osamu Kitamukai
- Eiji Nozaki
- Yasunori Kokusho
- Akihiko Karibe
- Jun Nawata
- Yusuke Takagi (ORCID: https://orcid.org/0000-0002-0305-1597)
- Dai Katayose (ORCID: https://orcid.org/0000-0002-8878-2304)
- Tôru Shimizu (ORCID: https://orcid.org/0000-0002-3950-5554)
- Jun Suzuki (ORCID: https://orcid.org/0000-0002-9164-6389)
- Akihiko Kikuchi (ORCID: https://orcid.org/0000-0002-7814-3656)
- Yukio Maruyama (ORCID: https://orcid.org/0000-0002-5602-8104)
- Jun Suenaga
- Motoyuki Matsui
- Shigefumi Fukui (ORCID: https://orcid.org/0000-0003-4881-4049)
- Syunsuke Tatebe
- Kousuke Takahashi
- T. Sugie
- Shin‐ichiro Oyama (ORCID: https://orcid.org/0000-0002-5831-6134)
- Yoshiaki Tamada
- Yasuhiko Sakata (ORCID: https://orcid.org/0000-0001-6809-8487)
- Hiroshi Mihara (ORCID: https://orcid.org/0000-0002-8427-2868)
- Akihiko Sugimura
- Yasumasa Yamamoto (ORCID: https://orcid.org/0000-0001-6905-6406)
- Kotaro Nochioka (ORCID: https://orcid.org/0000-0001-8297-8624)
- Saori Miyamichi-Yamamoto
- Takeshi Shinozaki (ORCID: https://orcid.org/0000-0001-6762-8490)
- Chiaki Takahashi (ORCID: https://orcid.org/0000-0003-3390-9563)
- Kunihiro Nishimura (ORCID: https://orcid.org/0000-0002-0639-0949)
- Jun Otomo
- Tetsuya Hiramoto (ORCID: https://orcid.org/0000-0002-1773-7637)
- Shuji Kotaka
- Atsushi Kato (ORCID: https://orcid.org/0000-0001-9144-3138)
- T. Tomioka
- Masaaki Nakayama (ORCID: https://orcid.org/0000-0002-6052-6202)
- Yasuhide Asaumi (ORCID: https://orcid.org/0000-0002-9009-7234)
- Yuji Wakayama
- Kaoru Iwabuchi
- K. Akai
- Tatsuya Komaru
- Toshikazu Goto
- Kohei Fukahori
- Masahide Kondo (ORCID: https://orcid.org/0000-0001-6021-4375)
- Takahide Suzuki
- Tomohiro Tada (ORCID: https://orcid.org/0000-0001-7221-8314)
- S Nakajima (ORCID: https://orcid.org/0000-0002-5898-7720)
- Nobuo Sekiguchi
- Satoru Takeda (ORCID: https://orcid.org/0000-0001-9547-1435)
- Shigeru Sasaki (ORCID: https://orcid.org/0000-0003-3786-4788)
- Shinya Sato (ORCID: https://orcid.org/0000-0002-2155-2379)
- Yusuke Yamada (ORCID: https://orcid.org/0000-0003-2684-516X)
- Nobuko Yamaguchi (ORCID: https://orcid.org/0000-0003-4838-3592)
- K. Oumi
- R. Tsuburaya (ORCID: https://orcid.org/0009-0003-4177-1397)
- J. Kimura
- Hiroshi Kanno (ORCID: https://orcid.org/0000-0003-3340-9462)
- Masataka Nakano (ORCID: https://orcid.org/0009-0006-9884-2768)
- Jiro Kikuchi
- Morihiko Takeda (ORCID: https://orcid.org/0000-0002-0434-3014)
- Yoshihiko Koseki (ORCID: https://orcid.org/0000-0003-0087-777X)
- T. Tajima
- Koji Fukuda (ORCID: https://orcid.org/0000-0001-7209-8420)
- Atsushi Kato (ORCID: https://orcid.org/0009-0000-6791-0963)
- Yutaka Miura (ORCID: https://orcid.org/0000-0002-0506-7138)
- Koki Aizawa (ORCID: https://orcid.org/0000-0002-9872-0641)
- Katsuhiko Sakurai
- K. Tanigawa (ORCID: https://orcid.org/0000-0001-9647-2552)
- Satoshi Watanabe (ORCID: https://orcid.org/0000-0001-6757-3514)
- Yuji Konno (ORCID: https://orcid.org/0000-0002-5056-0183)
- Masafumi Kitakaze (ORCID: https://orcid.org/0000-0001-5157-4213)
- Kenji Tamaki (ORCID: https://orcid.org/0000-0001-9890-3686)
- Kei Ito (ORCID: https://orcid.org/0000-0001-5792-3795)
- Hideyuki Kato (ORCID: https://orcid.org/0000-0001-9803-4871)
- Tomoaki Kagatani
- Koichiro Sugimura (ORCID: https://orcid.org/0000-0001-5354-9687)
- K. Komaki
- Ikuo OIKAWA
- Nobuyo Sekiguchi
- Mitsuaki Tanaka
- Hiroshi Tada (ORCID: https://orcid.org/0000-0003-2670-8982)
- Hiroki Shioiri
- Ryoji Koshida
- Hiromi Hamada (ORCID: https://orcid.org/0000-0002-0560-7034)
- K. Teramoto (ORCID: https://orcid.org/0000-0002-4217-9497)
- Takashi Shiroto (ORCID: https://orcid.org/0000-0002-8957-6203)
- Yoshihiro Fukumoto (ORCID: https://orcid.org/0000-0003-0516-770X)
- Hideaki Endo (ORCID: https://orcid.org/0000-0002-8522-1851)
- S. Baba (ORCID: https://orcid.org/0000-0001-6602-3043)
- Naomi Takahashi (ORCID: https://orcid.org/0000-0003-1938-158X)
- Kiyotaka Hao (ORCID: https://orcid.org/0000-0002-6841-9284)
- Yasuhiro Ito (ORCID: https://orcid.org/0000-0002-2069-4658)
- Kanichi Inoue
- Tsuyoshi Shinozaki
- Yukio Sugai (ORCID: https://orcid.org/0000-0003-4688-6233)
- Masashi Takeuchi (ORCID: https://orcid.org/0000-0002-4015-9599)
- Jun-ichi Koyama (ORCID: https://orcid.org/0000-0001-8625-8392)
- Masatoshi Ohe
- Takeshi Ishizuka
- Shigeru Sugaya
- S. Komatsu
- Junko Ohashi
- Masahiko Ogata
- Toshiki Tanikawa
- Setsuro Ibayashi
- Shu Suzuki (ORCID: https://orcid.org/0009-0004-9799-604X)
- S. Onodera
- Akio Fukui (ORCID: https://orcid.org/0000-0003-4524-3156)
- Toru Takii
- Ken Satoh
- T. Takada
- K Saji
- Kai Nagasawa
- N. Hoshi
- B.H. Ong
- Yutaka Kagaya
- T. Sakuma
- Takashi Watanabe
- Keishi Otsuka
- Yoshiaki Kikuchi
- S. Nagasawa
- Yoshiaki Sakata
- Masaharu Kanazawa
- Masafumi Sugi
- Isao Ohno
- M. Sugi
Institutions
- Tohoku University (JP)
- National Cerebral and Cardiovascular Center (JP)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1161/jaha.125.041208
- Citations
- 1
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.39