Reply to Comment by Quistorff: ATP is not consumed solely by hydrolytic reactions
A Comment to our recent paper that described a budget for brain metabolic water production claimed that all ATP produced by oxidation of glucose is consumed by hydrolysis, and that the net calculated production of metabolic water is equal to that obtained by combustion of glucose. However, ATP is synthesized and consumed by enzymatic reactions that do not involve water in the mechanism. Not all ATP consumed is hydrolyzed.
Authors
- Gerald A. Dienel (ORCID: https://orcid.org/0000-0001-8887-3057)
- Martin Lauritzen (ORCID: https://orcid.org/0000-0002-1517-1131)
Institutions
- University of Copenhagen (DK)
- University of New Mexico (US)
- University of Arkansas Medical Center (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s12987-025-00711-3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00