Effects of a Four‐Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial
This probiotic was effective in beneficially enriching the gut microbiota with potential to reduce systemic inflammation, shortening time-to-on following levodopa administration, and alleviating NMS burden in PwP experiencing constipation. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Gwénaëlle Le Gall (ORCID: https://orcid.org/0000-0002-1379-2196)
- Per Odin (ORCID: https://orcid.org/0000-0002-0756-7478)
- Anna Sauerbier (ORCID: https://orcid.org/0000-0003-0966-5933)
- Cristian Falup‐Pecurariu (ORCID: https://orcid.org/0000-0002-7394-7161)
- Alessandra Borsini (ORCID: https://orcid.org/0000-0003-4410-7865)
- Kristina Rosqvist (ORCID: https://orcid.org/0000-0002-3861-8012)
- Edoardo Moretto (ORCID: https://orcid.org/0000-0002-3546-6797)
- Gargi Mandal (ORCID: https://orcid.org/0000-0001-5767-4207)
- Miriam Parry
- Alexandra Rizos (ORCID: https://orcid.org/0000-0002-0935-9111)
- К. Ray Chaudhuri (ORCID: https://orcid.org/0000-0003-2815-0505)
- Valentina Leta (ORCID: https://orcid.org/0000-0002-5794-7540)
- Carolina Sportelli
- David Vauzour (ORCID: https://orcid.org/0000-0001-5952-8756)
- Dhaval Trivedi (ORCID: https://orcid.org/0000-0003-2319-8024)
- Daniel J. van Wamelen (ORCID: https://orcid.org/0000-0003-0921-5158)
- Pavlos Zinzalias
- Simon Gaisford (ORCID: https://orcid.org/0000-0003-1000-3208)
- Ana Rodriguez‐Mateos (ORCID: https://orcid.org/0000-0003-3242-402X)
- Alan Bonder (ORCID: https://orcid.org/0000-0001-6821-0416)
- Aleksandra Podlewska (ORCID: https://orcid.org/0000-0002-0805-3356)
- Jonas Ghyselinck
- Juliet Staunton (ORCID: https://orcid.org/0009-0009-9535-1199)
- Lucia Batzu (ORCID: https://orcid.org/0000-0001-6249-2803)
- Jonathan Timpka (ORCID: https://orcid.org/0000-0002-2577-8607)
- Trinette van Vliet
- Carmine M. Pariante (ORCID: https://orcid.org/0000-0002-9132-5091)
- Carmen Rodríguez‐Blázquez (ORCID: https://orcid.org/0000-0003-3829-0675)
- Benoît Marsaux (ORCID: https://orcid.org/0000-0001-5967-5414)
- Guy Chung‐Faye
- Frida Jernstedt
Institutions
- University of East Anglia (GB)
- Wellcome Centre for Human Neuroimaging (GB)
- University of Cologne (DE)
- King's College London (GB)
- Lund University (SE)
- Clinical Emergency Hospital Bucharest (RO)
- Transylvania University of Brașov (RO)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Parkinson's UK (GB)
- King's College Hospital NHS Foundation Trust (GB)
- Neuroscience Institute (IT)
- ProDigest (Belgium) (BE)
- Skåne University Hospital (SE)
- The London College (GB)
- King's College Hospital (GB)
- University Hospital Cologne (DE)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Parkinson's Foundation (US)
- University College London (GB)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1002/mds.70047
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17