Formylation of His Residues at Position 2 in Peptide <i>b</i> Ions due to Noncanonical C <sup>α</sup> ‐CO Bond Cleavage: Assignment of the <i>m/z</i> 166 Product Ion in Proteome Data

In peptide sequences containing N-terminus XH motifs, the histidine imidazole side chain facilitates C<sup>α</sup>-CO bond cleavage at residue X.

Authors

Marimuthu Vijayasarathy
P. Balaram (ORCID: https://orcid.org/0000-0002-6577-933X)
Manjunath A. Venkatesha
Sanjeev Kumar (ORCID: https://orcid.org/0000-0001-6653-0467)

Institutions

Tata Institute of Fundamental Research (IN)
National Centre for Biological Sciences (IN)
Propagation Research Associates (United States) (US)

Publication Details

Journal: Rapid Communications in Mass Spectrometry
Published: 2025-10-23
DOI: https://doi.org/10.1002/rcm.10154
Primary Topic: Mass Spectrometry Techniques and Applications
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Indian Institute of Science
Jawaharlal Nehru Centre for Advanced Scientific Research
Directorate for Biological Sciences
National Centre for Biological Sciences

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article

Formylation of His Residues at Position 2 in Peptide b Ions due to Noncanonical C ^α ‐CO Bond Cleavage: Assignment of the m/z 166 Product Ion in Proteome Data

Marimuthu Vijayasarathy, P. Balaram, Manjunath A. Venkatesha, Sanjeev Kumar

Oct 23, 2025

Rapid Communications in Mass Spectrometry

Mass Spectrometry Techniques and Applications

article

Formylation of His Residues at Position 2 in Peptide b Ions due to Noncanonical C ^α ‐CO Bond Cleavage: Assignment of the m/z 166 Product Ion in Proteome Data

Marimuthu Vijayasarathy, P. Balaram, Manjunath A. Venkatesha, Sanjeev Kumar

October 23, 2025article en

Abstract

In peptide sequences containing N-terminus XH motifs, the histidine imidazole side chain facilitates C<sup>α</sup>-CO bond cleavage at residue X.

Rapid Communications in Mass SpectrometryVol. 40(2)

Tata Institute of Fundamental Research (IN), National Centre for Biological Sciences (IN), Propagation Research Associates (United States) (US)

Indian Institute of Science, Jawaharlal Nehru Centre for Advanced Scientific Research, Directorate for Biological Sciences, National Centre for Biological Sciences

Openalex Percentile: Top 72%

Mass Spectrometry Techniques and Applications

DOI Open Access PDF OpenAlex

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Formylation of His Residues at Position 2 in Peptide <i>b</i> Ions due to Noncanonical C <sup>α</sup> ‐CO Bond Cleavage: Assignment of the <i>m/z</i> 166 Product Ion in Proteome Data — Marimuthu Vijayasarathy, P. Balaram, et al. · Rapid Communications in Mass Spectrometry (2025) | TGRS Research Map | TGRS