Dietary Patterns and Mental Health Across the Lifespan: A Systematic Review of Randomized Clinical Trials

In a world increasingly characterized by rises in anxiety, depression, mood disorders and cognitive decline, our mental well-being often depends not only on our environment, but also on our food. In this systematic review, 25 clinical nutritional trials analyzed the relationship between dietary patterns and mental health across the lifespan. The PubMed-Medline, Web of Science, Scopus and Cochrane Library databases were searched for relevant articles from 2013 published up to June 2025 and included studies with a minimum 3-month follow-up and a minimum of 50 participants. The results showed that, in most studies, the Mediterranean diet reduces depressive symptoms by 32–45%. It works because it is rich in polyphenols, omega-3 fatty acids and fiber; lowers systemic inflammation; promotes gut diversity; and improves dopamine and serotonin modulation. On the other hand, five studies have shown that the MIND Diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) (with daily leafy greens, berries at least twice a week, whole grains, legumes, olive oil and nuts) and a whole-food plant-based diet lower C-reactive protein and improve mood in patients with chronic stress and fatigue. Plants provide antioxidants and phytochemicals that neutralize oxidative stress in neurons. This report emphasizes the need to promote well-being and increase public demand for food that also improves quality of life and mental health.