Unravelling IPAF, VEDOSS and connective tissue diseases classifications through the mixed connective tissue disease spectrum

At MCTD diagnosis, fulfilment of IPAF and/or VEDOSS criteria was not predictive of evolution toward SSc, whereas antiphospholipid antibodies and low C3 and/or C4 were predictive of an evolution toward SLE. This suggests that MCTD patients should be excluded from IPAF and VEDOSS.

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Publication Details

Journal
RMD Open
Published
2025-10-01
DOI
https://doi.org/10.1136/rmdopen-2025-006145
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Unravelling IPAF, VEDOSS and connective tissue diseases classifications through the mixed connective tissue disease spectrum

Kévin Chevalier, Thomas Hanslik, Cécile Goujard, T. Papo et al.
RMD Open
Systemic Sclerosis and Related Diseases
article

Unravelling IPAF, VEDOSS and connective tissue diseases classifications through the mixed connective tissue disease spectrum

Kévin Chevalier, Thomas Hanslik, Cécile Goujard, T. Papo, Bertrand Dunogué, Maxime Samson, Jean‐Emmanuel Kahn, Benjamin Thoreau, Isabelle Koné‐Paut, P. Cacoub, H. Lévesque, Alexis Régent, Xavier Mariette, Karim Sacré, C. Agard, Benjamin Chaigne, Y. Benhamou, N. Costedoat‐Chalumeau, P. Duhaut, Raphaèle Séror, Félix Ackermann, Marc Michel, Véronique Le Guern, Luc Mouthon, Benjamin Terrier, Bernard Bonnotte, Jean M. Schmidt, Brigitte Bader-Meunier, Eric Hachulla, Bertrand Godeau, Pascal Cohen, O. Lambotte
article en

Abstract

At MCTD diagnosis, fulfilment of IPAF and/or VEDOSS criteria was not predictive of evolution toward SSc, whereas antiphospholipid antibodies and low C3 and/or C4 were predictive of an evolution toward SLE. This suggests that MCTD patients should be excluded from IPAF and VEDOSS.

RMD OpenVol. 11(4)
Hôpital Necker-Enfants Malades (FR), Université Paris Cité (FR), Université de Lille (FR), Université Paris-Saclay (FR), Centre Hospitalier Universitaire de Nantes (FR), Sorbonne Université (FR), Lille’s Cardiology Hospital (FR), Centre Hospitalier Universitaire de Tours (FR), Centre Hospitalier Universitaire Amiens-Picardie (FR), Assistance Publique – Hôpitaux de Paris (FR), CHU Dijon Bourgogne (FR), Pitié-Salpêtrière Hospital (FR), Centre d'Immunologie et des Maladies Infectieuses (FR), Hôpitaux Universitaires Henri-Mondor (FR), Hôpital Ambroise-Paré (FR), Hôpital Bichat-Claude-Bernard (FR), Centre Hospitalier Universitaire de Rouen (FR), Hôpital Foch (FR), Bicêtre Hospital (FR), Université de Rouen Normandie (FR)
Openalex Percentile: Top 57%
Systemic Sclerosis and Related Diseases
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