Investigation of the Relationship Between Serum Subfatin Levels and Clinical Outcome in Patients with Transient Ischemic Attack in the Emergency Department

Aim:We hypothesized that lower serum subfatin levels at admission might be associated with a higher risk of subsequent stroke in transient ischemic attack (TIA) patients.Therefore, this study aimed to examine the relationship between baseline subfatin levels and the occurrence of new cerebrovascular events at 28 and 90 days. Materials and Methods:Patients who were admitted to the emergency department and diagnosed with TIA between 01.04.2022 and 31.03.2023 were studied prospectively.Results: A total of 141 volunteers (71 patients and 70 controls) who met the criteria were included in the study.The median subfatin level of the patients was 1.51 [interquartile range (IQR): 25-75: 1.27-1.71]and the median subfatin level of the control group was 1.62 (IQR: 25-75: 1.13-2.32).There was a statistically significant association between coronary artery disease (CAD) and stroke development at 28 and 90 days [(p<0.05),(p<0.05)].Median subfatin levels were numerically lower in patients who experienced stroke within 28 and 90 days compared to those without subsequent stroke; however, these differences did not reach statistical significance (p>0.05).Therefore, no definitive conclusion can be drawn regarding the prognostic role of subfatin in this cohort. Conclusion:CAD was significantly associated with stroke occurrence at both 28 and 90 days, underscoring its role as a major predictor of adverse outcome in TIA patients.We also found that although subfatin levels were lower in patients who had a stroke within 28 and 90 days compared to patients who did not have a stroke, there was no statistically significant difference between them.