Ruminococcus torques ameliorates the inflammation bowel disease and gut barrier dysfunction by modulating gut microbiota and bile acid metabolism
Our findings demonstrated R. torques as a novel microbial therapeutic candidate for IBD management. The anti-colitis mechanisms involve the modulation of BA metabolic homeostasis, epithelial barrier reinforcement, and inflammation resolution.
Authors
- Youyou Luo (ORCID: https://orcid.org/0000-0002-0185-1371)
- Jingan Lou (ORCID: https://orcid.org/0000-0001-9142-5378)
- Jie Chen (ORCID: https://orcid.org/0000-0002-4029-4192)
- Jindan Yu (ORCID: https://orcid.org/0000-0002-3390-1660)
- Yan Ni (ORCID: https://orcid.org/0000-0003-1779-7266)
- Yao Lv (ORCID: https://orcid.org/0000-0001-9434-9665)
- Youhong Fang (ORCID: https://orcid.org/0000-0003-3686-1016)
- Yue Lou (ORCID: https://orcid.org/0000-0003-4997-2962)
- Yu Yu (ORCID: https://orcid.org/0000-0002-0209-0586)
- Xiaoxi Wang (ORCID: https://orcid.org/0000-0001-5560-7908)
- Weizhong Gu (ORCID: https://orcid.org/0000-0002-3983-1413)
- Hong Zhao (ORCID: https://orcid.org/0000-0001-8991-7824)
- Kerong Peng (ORCID: https://orcid.org/0000-0001-6321-5672)
Institutions
- Children's Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s12967-025-07192-w
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China